Research Investigator Analytical Development
Location: Boston
Posted on: June 23, 2025
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Job Description:
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Center Americas, Inc. for the following job opportunity: JOB
LOCATION: Cambridge, MA POSITION: Research Investigator Analytical
Development POSITION DESCRIPTION : Takeda Development Center
Americas, Inc. is seeking a Research Investigator Analytical
Development with the following duties: Independently design, plan
and execute studies on new development candidates to elucidate
fundamental physicochemical properties and behaviors that enable
lead candidate selection and downstream CMC development; contribute
to a cross-functional Pharmaceutical Sciences team responsible for
overseeing API salt and polymorph selection and subsequent
development activities; use analytical techniques offline and
potentially inline to characterize API form and morphology
development; develop non-GLP and GLP formulations based on the
physical chemical properties of molecules and their route of
delivery to support pre-clinical studies; includes the use of
in-silico assessments; conduct biorelevant in vitro studies to
assess potential in-vivo performance and impact of API and drug
product changes during development lifecycle; be responsible for
significant or sole technical leadership within a project and
support project strategy development across projects within the
department or cross functionally; interface with individual
Pharmaceutical Science colleagues and cross functional project
teams to ensure that development activities are consistent with
physicochemical properties of API; represent functional area on
departmental or cross functional teams communicating and aligning
Pharmaceutics Research activities and milestones; collaborate with
Drug Safety to transfer formulations to CRO’s for non-GLP and GLP
toxicology studies; may serve as a technical expert in mentoring
junior team members; integrate scientific and technical efforts
around cross functional issues; plan and implement resolutions to
technical problems and issues; support local initiatives which may
include technical or process related work streams; author technical
reports and contributes to regulatory filings. Up to 10% domestic
travel required; Up to 20% remote work allowed. REQUIREMENTS:
Bachelor’s degree in Chemistry, Analytical Chemistry, Biology,
Pharmaceutical Sciences, Materials Science and engineering, or
other Life Science related degree plus 5 years of prior experience
OR Master's degree in Chemistry, Analytical Chemistry, Biology,
Pharmaceutical Sciences, Materials Science and engineering, or
other Life Science related degree plus 3 years of prior experience.
Prior experience must include: Develop early-stage formulations of
active pharmaceutical ingredients (APIs) to enable in-vivo animal
studies, optimizing drug product properties, and supporting initial
pharmacokinetic and toxicology assessments; Conduct solid state
physical and chemical characterization using HPLC, PXRD, TGA, DSC,
DVS, SEM, and FTIR, etc., to evaluate solid state stability, and
form/structural properties for optimal formulation development;
Develop and execute analytical methods (HPCL, GC, MS, KF etc) for
API and Drug Products to enable characterization of materials key
properties and stability to ensure quality and enable development
of processes (i.e. purity, assay, identification); Design and
execute biopharmaceutics studies of drug candidates to assess
formulation performance and facilitate drug candidate selection;
Develop simulation and mathematical models and utilize in-silico
tools, including GastroPlus, Phoenix WinNonline, etc., to predict
drug candidate properties and in vivo drug performance that enable
optimization of drug products, and potentially aid in regulatory
submissions. Full time. $108,600.00 - $165,600.00 per year.
Competitive compensation and benefits. Qualified applicants can
apply at https://jobs.takeda.com . Please reference job R0149050 .
EOE Any individual may provide documentary evidence bearing on this
application, with information on available workers and information
on wages and working conditions, to the Certifying Officer, U.S.
Department of Labor, Employment and Training Administration, Office
of Foreign Labor Certification, 200 Constitution Avenue, NW, Room
N-5311, Washington, DC 20210. Locations Boston, MA Worker Type
Employee Worker Sub-Type Regular Time Type Full time
Keywords: , Westfield , Research Investigator Analytical Development, Science, Research & Development , Boston, Massachusetts
